Science has always been my way of exploring how small molecular changes can shape something as complex as the brain. I earned my BSc in Biochemistry from the University of Barcelona and my MSc in Neurochemistry with Molecular Neurobiology from Stockholm University. For my master’s thesis, conducted in collaboration with Karolinska Institutet, I investigated how antisense oligonucleotides (ASOs) could reduce cognitive deficits caused by cranial radiotherapy in childhood cancer survivors by promoting neural regeneration and preventing degeneration. After graduating in 2024, I stayed in the same research group at Karolinska Institutet until March 2025, studying sex differences in brain irradiation responses across the cerebellum, cortex, and hippocampus. I am now thrilled to continue my scientific journey as a PhD fellow within the EFFecT program at Servier, Paris. 

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Beyond the lab, I love reading, going to the theatre, concerts, and musicals, discovering new TV series, and spending time on creative crafts. 

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DC8: Optimizing ASO brain uptake and retention time

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Supervisor: Dr. H. Tran

External mentor: Dr. A. Garanto

Host Institute: Institut de Recherches Servier, France (www.servier.com)

Secondments planned: Université de Versailles Saint-Quentin-en-Yvelines, France; Leiden University Medical Center, The Netherlands

Doctoral program: Doctoral program Life Sciences and Health of Université Paris-Saclay

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Starting date: November 1st, 2025

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Project description:

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Antisense Oligonucleotide therapeutics are emerging as an innovative potentially transformative medicine for certain brain disorders with no therapeutic options such as spinocerebellar ataxias. We are interested in understanding better how sequences and/or modified chemistries can impact their potency, uptake, biodistribution, safety and elimination half-life with a particular focus on the cerebellum. The candidate will benefit from preliminary data generated in the host laboratory on protein modifier regulating ASO uptake. Biodistribution, potency and safety profile of a panel of different ASOs in cerebellum other brain regions in rodent and large animal species will also be leveraged to support the PhD thesis.